John howell mp biography of alberta
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Published in final edited form as: Cancer Cell. 2007 May;11(5):395–406. doi: 10.1016/j.ccr.2007.02.025
SUMMARY
PPARγ is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARγ ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARγ activation with chemotherapeutic agents in current use for specific cancers. We observed a striking synergy between rosiglitazone and platinum-based drugs in several different cancers both in vitro and using transplantable and chemically induced “spontaneous” tumor models. The effect appears to be due in part to PPARγ-mediated downregulation of metallothioneins, proteins that have been shown to be involved in resistance to platinum-based therapy. These data strongly suggest combining PPARγ agonists and platinum-based drugs for the treatment of certain human cancers.
INTRODUCTION
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Civilian Records relating to Slavery
The records referenced in these pages highlight some of the records pertaining to slavery that are available at the National Archives. Information and records are arranged bygd government branch and record group. Series, folders, and items are identified with brief descriptions. This page may provide actual documents that have been digitized and are in the National Archives Catalog. Some of the records are microfilmed, and have been noted.
For more upplysning, see Walter B. Hill Jr.'s Prologue article on this topic, and the handout - Federal Records that Help Identify Former Enslaved People and Slave Holders
Return to American Slavery Main Page
Civil Records
RG 29 Records of the Bureau of the Census
Publications of Population Schedules (US Census) during the time of Slavery
Links will take you to the National Archives Catalog description. Some Census records are available in
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Archives West Finding Aid
A.C. Peale Diary/ Journal
A.R. Marvin Journal
Applications for Grants for Fryxell
Applications for Jobs- Nepotism
Bibliographical Sketch of F.V. Hayden by A.C. Peale
Biography of A.C. Peale by F.M. Fryxell
Chart of Stratigraphic Units Named by Hayden and Still Used
Civil War Veterans in Hayden Parties
Coe Collection- Raynolds, Warren Expeditions
Colleges and Universities Attended by Hayden Men
Denver Federal Center- USGS Field Archives
Eli Lilly Collection
F.B. Meek Journal
F.B. Meek Journal- Down River
F.B. Meek Journal- Up-River
F.V. Hayden- Last Years, Illness and Death
F.V. Hayden Publication
General Services Administration